Synthesis and antimicrobial activity N-heterylidenehydrazides 4-nitroimidazole-5-thioacetic acid

Abstract

In modern methodologies for the rational design of new biologically active substances and lead compounds for the creation of medicinal products, imidazole-containing structures play a key role due to their powerful medical and biological potential. An important place among imidazoles is occupied by various types of their functionalized derivatives, which are characterized by antibacterial, antifungal, anticancer, and antituberculosis action. Modification of the nitro-containing imidazole ring with other functional groups proved to be quite productive for the construction of structures with increased pharmacological potential. The aim of the study. Realization of targeted synthesis of new 4-nitroimidazole structures with 5-sulfanyl-functionalized fragments, additionally modified by pharmacophoric hydrazide- hydrazone groups, and investigation of their antimicrobial action. Materials and Methods. Organic synthesis, analytical and spectral methods, pharmacological screening, molecular docking.