Профилактика ожирения и неалкогольного стеатогепатита у крыс антидисбиотическим средством

Abstract

Aim: To determine of prevention and treatment effect of antidysbiotic formulation on obesity and NASH in rats. Methods: The experimental obesity and NASH were induced by feeding rats with a high fat diet (HFD) (fodder, plus 15 % sunflower oil - 40 days) and driaking water with lincomycin at a dose of 60 mg/kg day for 5 days. The duration of experiment was 41 days. One group of rats re­ceived HFD and lincomycin, received antidysbiotic formulation Quertulin (quercetine + inuline + Ca-citrate) in dose 300 mg/kg 40 days. Determined morphometric parameters like body mass, body mass index, content of triglyceride (TG) and cholesterine (Ch) of liver and serum cjntent of bilirubine and activity of ALT and in serum, alkaline phosphatase (AP).Results: At obesity and NASH body mass, body mass index, content of TR, Ch, in liver and serum were increased; in serum content to bilirubine and activity to ALT and AP were increased. aking quertulin normalized morphometric and biochemic indexis in liver and serum. Conclusion: Antidysbiotic formulation quertulin made of prevention and treatment effect on besity and NASH.Сочетание высокожирового рациона и кишечного дисбиоза вызывает у крыс развитие ожирения и неалкогольного стеатогепатнта (НАСГ). Введение антидисбиотического средства «Квертулин» (кверцетин + инулин + цитрат кальция) предотвращает развитие ожирения и НАСГ.