Histological study of the placental villous tree in chronic basal deciduitis and iron deficiency anemia of pregnant women

Abstract

Our previous studies have shown that the combination of chronic inflammation of the basal plate with iron deficiency anemia (IDA) in pregnant women exerts a dual damaging effect on the placenta. Chronic basal deciduitis leads to impaired uteroplacental circulation, while anemia aggravates ischemic and hypoxic processes. Since the villous component is the main morphofunctional unit of the placenta, its damage determines the severity of placental insufficiency. The study of villous tree alterations in the combination of these pathologies provides deeper insight into the mechanisms underlying its development. The aim of the study. To study the morphological features of the placental villous tree in chronic basal deciduitis and iron deficiency anemia in pregnant women. Material and methods. A total of 82 placentas were examined. The material was fixed for 48 hours in 10% neutral buffered formalin, followed by standard dehydration and paraffin embedding. Serial 5 μm sections were prepared and stained with hematoxylin and eosin, as well as by the Slynchenko method to assess connective tissue structures.