Separate consequences of the impact of post-covid syndrome on chronic pathology

Abstract

In Ukraine, the coronavirus infection Covid-19 (a new type of pneumonia) was first diagnosed on March 3, 2020 in Chernivtsi. On March 13, the first fatal case due to coronavirus infection was recorded. This infectious disease quickly spread worldwide, that is, to the scale of a pandemic, and is currently characterized by a permanent wave course with a periodic increase in the number of cases due to the virus's ability to rapidly mutate. One of the most interesting working hypotheses, which is based on the processing of a huge array of data obtained during the collection of material for PCR research, using the most modern methods of computational systems biology and which is able to explain in the most complete volume the options for the formation of severe manifestations of the systemic inflammatory response in coronavirus infection, is the bradykinin storm (BSS) model: an imbalance between excessive ROS formation and PRZ insufficiency – endothelial destruction (EDF), accompanied by microcirculation disorders; violation of the blood coagulation cascade, thrombovasculitis. Microangiopathy and hypercoagulation are the basis of multisymptoms in COVID-19; increased oxidative stress suppresses the biosynthesis and availability of NO. This hypothesis is able to explain the multisymptoms of COVID-19, including some of its most strange manifestations. The aim of the study is to assess the consequences of the impact of post-covid syndrome on chronic pathology