Features of changes lipid peroxidation and oxidative modification of proteins in the blood and liver of adult rats with different types of acetylation in poisonings manganese chloride.

Abstract

The growing anthropogenic load on environmental objects in the form of compounds of a chemical, physical and biological nature is quite serious. Among man-made chemical pollutants, lead and its compounds occupy a special place, which are characterized by high toxicity and a high ability to accumulate both in ecosystems and in human and animal bodies. There is an opinion that variations in the response of different individuals to environmental factors may be related to the features of the genotype to the genetically programmed system of biotransformation, degradation and removal of xenobiotics. The aim of the study. To explore indices of lipid peroxidation (LPO), antioxidant protection (AOP), and oxidative modification of proteins (OMP) in rat blood and liver under subacute exposure to MnCl₂, considering acetylation type and dose input, and to identify possible markers of susceptibility to the harmful effects of MnCl₂.