The effect of Sars-CoV-2 on the condition of the placenta and the fetus due to infection in the first trimester.

Abstract

The body of women during pregnancy undergoes significant changes, which makes them more vulnerable to infectious diseases during pregnancy, since immunological changes during pregnancy increase its sensitivity to both pathogenic and conditionally pathogenic microorganisms. It is believed that pregnant women with COVID-19 are more likely to develop severe complications, but the literature on this issue is controversial, as is the issue of the likelihood of placental and fetal impact. It has been established that the fetus can be directly affected by a viral infection as a result of vertical transmission or indirectly through the impression of the placenta. Other studies indicate that indicators of placental inflammation do not differ between patients with COVID-19 and healthy controls. Thus, the statement regarding the increased risk of complications is debatable, given the increased surveillance and clinical response to disease during pregnancy, which makes the problem relevant and worthy of further research in order to prevent complications. The aim of the study. To assess the impact of the SARS-CoV-2 virus in a mild and moderate form of the disease when infected before 12 weeks of pregnancy on the subsequent course of pregnancy, in particular the condition of the placenta and fetus.