Changes in catalase activity in the blood of rats under the effect of mercury dichloride against a background of salt loading

Abstract

Antioxidant defense processes play a significant role in the pathogenesis of various diseases, as the imbalance between the activation of free radical oxidation of macromolecules and the failure of the antioxidant defense system can accelerate the development of various pathological processes underlying kidney diseases. One of these enzymes is catalase (CAT) [EC 1.11.1.6], which breaks down hydrogen peroxide formed by the action of aerobic dehydrogenases. The main function of catalase in the cell is the decomposition of hydrogen peroxide formed during the dismutation of the superoxide anion radical. CAT is present in the blood, bone marrow, mucous membrane linings, liver, and kidneys. In many tissues, including the kidneys, there are microbodies, and peroxisomes, rich in aerobic dehydrogenases and catalase. Therefore, the study of antioxidant defense enzyme activity, particularly catalase, which maintains the oxidant-antioxidant balance in the blood, is relevant. The aim of the study. To determine the specific effects of salt loading in mercuric nephropathy on changes in catalase activity in the blood of rats.