Features of structural changes of the hypothalamic supraoptic nucleus in rats during the early diabetes 2

Abstract

«Diabetes is currently a global health burden affecting over 537 million people worldwide» (Mosili P., 2024). Various complications, such as cardiovascular and chronic kidney disease, are widely reported and studied, while studies about the influence on the brain are not so common. The aim of the study. To determine the structural organization of the hypothalamic supraoptic nucleus in rats with streptozotocin-induced diabetes. Materials and Methods. In the experiment, mature rats were used and modeled with streptozotocin-induced diabetes. On the 14th day of the experimental diabetes development in rats, quantitative cyto-myeloarchitecture parameters, and histological and ultrastructural changes in the anterior hypothalamic supraoptic nucleus were determined.