DYNAMICS OF MICROBIOTA CHANGES IN THE REGION OF INTESTINAL SUTURES UNDER EXPERIMENTAL CONDITIONS OF THEIR LEAKAGE

Abstract

Chronological dynamics of changes of quantitative and qualitative composition of microflora in the intestinal sutures region has been researched on the anastomotic leaks model in 75 experimental rats. It has been established that an exponential increase of total number of microorganisms with the changes of population and typical composition of intestinal microflora occurs in the region of applied sutures under the conditions of their leakage. In 12-24 hours a MC index rising is mainly due to autochthonous flora, and after 3-5 days – by increasing the number of obligate anaerobes, along with decreasing of facultative ones concentrations.