Abstract:
This study investigated to detect the content of remodeling markers of the respiratory tract in the exhaled breath
condensate (EBC) of children with bronchial asthma (BA). Materials and Methods: The study was in clinical groups of
children with BA were formed on the indices in sputum supernatant: the Group I ‑ “a high risk group” of bronchial remodeling
(37 patients with vascular endothelial growth factor (VEGF) more than 80 ng/ml, and matrix metalloproteinase‑9 (MMP‑9)
more than 5.2 ng/ml), the Group ІІ ‑ “a moderate risk” of bronchial remodeling (41 patients with VEGF more than 80 ng/ml,
and MMP‑9 <5.2 ng/ml, or VEGF <80 ng/ml, and MMP‑9 more than 5.2 ng/ml), the Group ІІІ ‑ “a low risk” of bronchial
remodeling (38 patients with VEGF did not achieve 80 ng/ml, and ММР‑9 <5.2 ng/ml). Results: The results obtained enable
to believe that in EBC of children with a high risk of bronchial remodeling was higher azoalbumin olysis (1.8 ml/h comparison
of Group II ‑ 1.5 ml/h, P = 0.038, and Group III ‑ 1.4 ml/h, P = 0.007), high catalase activity (81.26 comparison of other
group ‑ 50.7, P = 0.06, and 47.07, P = 0.052 μmol/min/mg of protein). Furthermore, in the clinical Group I, the content of
nitrogen monoxide metabolites (53.5 mcmol/L) comparison of Group II of children (48.7 mcmol/L, P = 0.28) and the Group III
(41.7 mcmol/L, P = 0.085). Conclusions: In children with a “high risk” of respiratory tract remodeling more significant
inflammatory process in the bronchi is found than in children with a “low risk.”
