Поєднання шизофренії та соматичної патології

Abstract

Schizophrenia patients frequently develop somatic co-morbidity. Schizophrenia is a complex disorder, with a high heritability, yet little is known about the underlying mechanisms. The etiology involves multiple genes, interacting biological pathways, and a variety of environmental risk factors. Schizophrenia is, however, increasingly recognized as a systemic disorder and these patients face an additional burden in terms of somatic comorbidity implying overlapping and interacting disease mechanisms that involve neurotransmitter, inflammatory, endothelial and hormonal pathways among others. Patients suffering from schizophrenia and related psychoses run a substantial risk of developing diabetes mellitus, metabolic syndrome, hypertension, cardiovascular diseases, lung diseases such as COPD, hypothyroidism and visual problems.