Concentration changes of apoptosis markers of endotheliocytes in the blood plasma of patients suffering from hypertensive dyscirculatory encephalopathy and methods of its correction.

Abstract

Objective: Concentration of molecules sCD95, sFas-L, sCD117 and activity of caspas-1,-3,-8 in the blood plasma before and after the course of taking Glutargin preparation containing arginine in patients with hypertensive dyscirculatory encephalopathy stage1. Methods. 24 patients suffering from hypertensive dyscirculatory encephalopathy stage 1 have been examined. The average age of the patients under study constituted 45,3±7,59 years old. The results were compared with analogous indices of 15 practically healthy persons comparable as to the age and sex with patients under study. Results: sCD95 content decreases 22% and sCD117 level increases 44% in the blood plasma accompanied by an increase of activity of kaspaz-1 in the group of patients under observation in comparison with the group of control. Hereby, the activity of kaspaz-3, and -8, sFas-L content in the blood do not change. Treatment of patients using glutargine decreases sCD95 plasma content 28% normalizes sCD117 level in the blood and doesn't influence upon concentration sFas-L and activity of kaspaz-1,-3,-8 in the blood plasma. Conclusions: The results of the research showed, that the intensity of both cell division and their apoptosis had been sharply increasing on endothelial level since the first stage of hypertensive dyscirculatory encephalopathy Glutargin usage in patients suffering from hypertensive dyscirculatory encephalopathy practically eliminates the determined factors of apoptosis stage1 and activity of kaspaz-1,3,-8 in the blood plasma that pathogenetically substantiates the expediency of the use of preparations containing arginin in case of cerebrovascular diseases.