The state of the prooxidant system in the cerebral cortex of rats with scopolamine-induced neurodegeneration and under the influence of enalapril

Abstract

The results of the study of peroxidation of proteins and lipids of the cerebral cortex under the conditions of suppression of central cholinergic effects by scopolamine indicate the development of cerebral degeneration. After the administration of enalapril, the degree of oxidative modification of proteins decreases and the content of TBCAP significantly decreases. The results obtained indicate the ability of enalapril to inhibit the development of neurodegeneration in scopolamine-induced brain damage.