The influence of chronic exogenous hypoxia on the ionoregulatory function of the kidneys of rats.

Abstract

The effect of hypoxia on numerous physiological and biochemical processes in tissues and cells is twofold and oppositely directed. Renal parenchymal hypoxia has been documented under a large number of clinical conditions, and in most cases, it contributes to the progression of chronic kidney diseases. However, one of the factors, on which the manifestations of multiorgan, morphofunctional disorders that are formed at the systemic level under the influence of hypoxia depend, is the duration of hypoxic exposure. Therefore, knowledge of the mechanisms of oxygen deficiency compensation and the mechanisms of adaptation to hypoxia in the dynamics of its development has not only theoretical but also applied significance. At the same time, the state of the ionoregulatory function of the kidneys under the conditions of chronic exogenous hypoxia has not been sufficiently studied. The aim of the study. Study of the influence of chronic exogenous hypoxia in the dynamics of its development on the state of the ionoregulatory function of the kidneys of rats.