Assessment of the role of ATP-dependent potassium channels in mechanisms of acid-base balance.

Abstract

Disruption of homeostasis in hypoxia is followed by dysfunction of the systems and organs that regulate the acid-base state. The multifaceted mechanisms of the pH control system indicate that maintaining interstitial and intracellular pH within a narrow range is of primary physiological importance. Scientific evidence indicates that many acid-sensitive ion channels and receptors play a role in the acid-sensitivity of the body's responses, acid-induced pain, and acid-induced regulation of homeostatic responses. Healthy kidneys correctly coordinate several physiological reactions in conditions of acute and chronic disturbances of the acid-alkaline balance. However, damaged kidneys have a reduced ability to adapt to such problems. Not only secretion and maintenance of electrolyte balance, but potassium ion channels also regulate cell volume; they are integral to cellular functions in all tubular cells due to their key role in generating the cell's negative electrical potential, which affects the transmembrane movement of many essential solutes. In this work, we investigate the main changes in renal responses to maintaining acid-base balance and show how they are interrelated with activating ATP-sensitive potassium channels. The aim of the study was to study the indexes of renal acid regulation in acute hypoxia under the influence of adenosine triphosphate-sensitive potassium channels activator flocalin.