Characteristics of urinary calcium and phosphates excretion in the dynamics of experimental diabetes mellitus development.

Abstract

Convincing data are indicative of a tendency to decrease bone mass and change of the bone tissue microarchitecture, observed in case of diabetes mellitus (DM). At the same time, the state of human mineral metabolism and bone remodeling is largely determined by the activity of the kidneys as the main efferent link of the regulation of water-salt metabolism. As a target organ and the site of degradation of most calcitropic factors, the kidneys significantly affect calcium homeostasis and vitamin D metabolism, and renal disorders are undoubtedly considered a risk factor for the development of secondary osteoporosis. Since diabetic nephropathy is one of the leading causes of renal failure among the numerous chronic complications that constantly develop against the background of DM, regardless of its type and duration, it is reasonable to clarify the role of renal dysfunction in the development of mineral metabolism disorders in case of DM. The aim of the study. The research is aimed at exploration of the peculiarities of calcium and phosphates excretion in the dynamics of experimental diabetes mellitus development.