Determination of the detoxification opportunities of the kidneys in sepsis.

Abstract

Factors of endogenous intoxication usually include microorganisms and their products of life, bacterial endo- and exotoxins, intermediate and final products of normal metabolism (in excessive concentrations), components of cellular, tissue, organ, and integrative regulatory systems (in pathologically high concentrations), products of distorted metabolism, toxic substances of intestinal origin. The composition of toxic substances also includes medium-mass molecules (MAM), which have sufficiently high biological activity. In particular, they have neurotoxic, cardiotoxic, hepatotoxic, and nephrotoxic activity, cause secondary immunodepression, etc. The aim of the study. To investigate the detoxification function of the kidneys using the example of calculated modifications of the paramecium test and kinetic parameters of medium molecules in patients with sepsis under infusion load conditions.