The progins variant of the progesterone receptor gene PGR and its influence on placental endocrine function in the risk of preterm labor.

Abstract

Progesterone receptors, encoded by the PGR gene, are responsible for the key physiological actions of progesterone, a hormone essential for a successful pregnancy. The PROGINS variant is one of the most widely found variants of the PGR gene. Genetic heterogeneity means that some women may have less effective forms of progesterone receptors, which can lead to clinical issues. Besides fertility challenges, these women might also respond differently to progesterone replacement therapy. The aim of the study. Assess how the PROGINS variant of the PGR gene influences hormonal levels and the outcomes of progesterone deficiency treatment in pregnant women at risk for preterm labor.