The effect of different X-ray radiation doses on the rat liver lipid peroxidation products.

Abstract

The problem of low-intensity radiation impact has become particularly acute after the Chernobyl disaster, when a significant number of people and animals were exposed to radiation. The effect of ionizing radiation is primarily initiated by the radiolysis intermediate products of intracellular water and changes in the formation of bioradicals as a result of these processes. Under such conditions, the level of lipid peroxides as the indicators of membrane integrity is changed, and their structure alterations determine the functional consequences of radiation exposure on the organism. At the same time, the literature concerning the impact of low doses ionizing radiation during fractionated irradiation on the liver lipid peroxidation (LPO) is contradictory. A great amount of experimental data has been accumulated regarding the study of sublethal and lethal dose radiation effects on the balance of the “LPO – antioxidants system” (AOS). However, insufficient attention has been given to the changes in this system under prolonged fractionated irradiation over time after its cessation. The aim of the study. To study the peculiarities of different dose fractionated X-ray irradiation effects on the dynamics of lipid peroxidation (LPO) in the liver at various time points following the exposure.