The features of the nonalcoholic steatosis and steatohepatitis depending on the presence of comorbid chronic kidney disease and obesity.

Abstract

Nonalcoholic steatohepatitis (NASH) is increasingly recognized as major health concerns due to their growing prevalence in the global population. These conditions are closely linked to metabolic disorders, obesity and chronic kidney disease (CKD), making their management more complex in patients with comorbidities. The coexistence of CKD and obesity significantly affects the progression and prognosis of liver diseases, contributing to a higher risk of fibrosis, liver failure, and cardiovascular complications. Understanding the specific features of NAFLD/NASH in patients with CKD and obesity is crucial for improving diagnosis, treatment strategies, and outcomes in this vulnerable population. Hence, investigating the interplay between these conditions is of paramount importance for clinicians and researchers alike. The aim of the study. To find out the likely changes in the liver of patients with non- alcoholic liver steatosis and steatohepatitis depending on the presence of comorbid chronic kidney disease and obesity