Effects of combined alcohol intoxication and light exposure on renal antioxidant system in rats.

Abstract

Despite the widely recognized negative impacts of excessive alcohol consumption on human health, alcohol use remains common in society. The World Health Organization (WHO) reports that alcohol abuse is responsible for approximately three million deaths annually worldwide, as well as for disabilities and organ damage. In contemporary life, ethanol consumption frequently coincides with exposure to other harmful factors, including disruptions in light cycles. Modern individuals are often exposed to light nearly constantly, with night shifts, air travel, jet lag, and active nightlife all contributing to disturbances in circadian rhythms. Under normal conditions, these biological rhythms are regulated by melatonin, a hormone primarily secreted in darkness. Even minimal light exposure can inhibit its production. Research has demonstrated that melatonin possesses a broad range of biological effects, with its primary function being a potent antioxidant action. The aim of the study. The study aims to examine melatonin influence on activity of antioxidant enzymes, specifically catalase, glutathione peroxidase and glutathione-S-transferase in the kidneys of rats subjected to alcohol intoxication and combined alcohol and constant light exposure.