Regularities of ontogenetic transformations of the mesonephros of humans and domestic pigs in the prenatal period.

Abstract

Previous research has not conclusively clarified the process of angiogenesis in the kidneys that are being formed. Since there are no detailed studies of the microcirculatory bed of the mammalian mesonephros, this is of fundamental interest. The revealed ability to stimulate local angiogenesis and feed from the appropriate vascular bed creates the potential for metanephros transplants, which is important for practical medicine. Therefore, deepening knowledge about the peculiarities of topographical and anatomical transformations of organs and structures of the urinary system of humans and domestic pigs can help in solving the clinical task – the development of kidney xenotransplantation. The aim of the study. To determine the peculiarities of the sources of the bookmark and the chronological sequence of topographical and anatomical transformations of the organs and structures of the urinary system of humans and domestic pigs. Material and methods. Specimens of 12 human and 8 domestic pig pre-fetuses were studied. A set of morphological research methods was applied, which included microscopy, three- dimensional reconstruction, morphometry and statistical analysis. Periodization of prenatal development from the standpoint of comparative morphology was carried out according to Carnegie stages.