Results of electron microscopic analysis of the use of autologous mesoconcentrate products – plasma rich in growth factors (PRGF).

Abstract

The use of blood plasma in the medical industry and practice has not only made geographical progress, but also significantly expanded the indications for therapeutic and prophylactic treatment. The scientific vector focuses not only on growth factors, but also on a fibrin fiber-based matrix that preserves the natural processes of blood clotting, which is due to the conversion of soluble fibrinogen into an irreversible fibrin gel, of which platelet-rich plasma is and remains an integral part. Proper protocol ordering of fibrin strands ensures the formation of a three- dimensional structure that serves not only as a biological framework with multifunctional properties, but also contains all genetic information with full stimulating content, with a spectrum of active trophic and repair factors - growth factors, in particular, of platelet origin. This study will provide an understanding of the differentiation of mesoconcentrate products by fibrin fiber diameter and density for their clinical use, the formation of a matrix base with the preservation of interfibrin spaces for continuous processes of trophic support and constant physiological remodeling.