Systemic content of eicosanoids in patients with chronic obstructive pulmonary disease concomitant with coronary heart disease

Abstract

Abstract. In paper we investigated the content of eicosanoids – leukotriene B4 and thromboxane A2 (by stable metabolite TxB2) in the blood serum and urine in patients with COPD, combined with СHD. We investigated 37 patients with exacerbation of COPD (clinical group B, GOLD II) associated with CHD – the main group, 27 patients with exacerbation of COPD (Ist comparison group) and 30 patients with coronary heart disease, stable angina pectoris (IInd comparison group). Our research revealed the highest concentrations of LTB4 and TxB2 in the blood serum of patients with COPD associated with CHD, comparing to patients with COPD without CHD and with CHD without COPD that was accompanied by increasing of their excretion with urine. The strength and direction of correlation links between concentrations of these eicosanoids in blood serum and indices of bronchial patency indicate their negative influence on bronchial patency of patients with a combination of COPD and CHD.