Changes in acetylcholinesterase activity in patients with bronchial asthma with comorbid chronic acalculous cholecystitis

Abstract

Bronchial asthma (BA) is a global problem in internal medicine that is leading among respiratory diseases; therefore, it remains an actual problem for scientific research within Ukraine and worldwide. More than 300 million people globally have asthma, with up to 10% of all patients who have severe asthma. There is an increase in the tone of bronchial smooth muscles and hypersecretion of mucus in patients with bronchial asthma, probably due to the increased cholinergic activity. Acetylcholine is synthesized from choline and acetyl-CoA mainly by the enzyme choline acetyltransferase expressed in airway epithelial cells, which release acetylcholine. Acetylcholine binds to muscarinic receptors, which play a key role in the pathophysiology of asthma, leading to bronchoconstriction, increased mucus secretion, inflammation, and airway remodeling.