The activity of antioxidant enzymes in chronic obstructive pulmonary disease in combination with comorbid obesity

Abstract

Background. Chronic obstructive pulmonary disease (COPD) is one of the most common diseases in the world, whose mortality continues to increase. The focus of modern medical science and public health is obesity too, because the number of patients are steadily increasing and doubling every three decades. The aim of the study. To study the dependence of the parameters of antioxidative enzymes in the blood in patients with chronic obstructive pulmonary disease, depending on the severity of accompanying obesity. Materials and methods. The study involved 19 patients with COPD without obesity, 48 patients with COPD, combined with obesity grade I, II, III. We determined the content of reduced glutathione levels, level of ceruloplasmin in serum, activity of glutathione peroxidase, glutathione-S-transferase, copper / zinc -superoxide dismutase, catalase activity in the blood. Results. Found that in chronic obstructive pulmonary disease observed decrease in reduced glutathione and activities of copper / zinc superoxide dismutase and catalase in blood with simultaneous increased ceruloplasmin and glutathione peroxidase activities and glutathione-S-transferase levels. These changes are compounded with increasing body mass index and is most observed in the third degree of accompanying obesity. Conclusions. In patients with chronic obstructive pulmonary disease, combined with obesity, there is decompensation of functioning antiradical protection systems, resulting decrease in reduced glutathione and activities of superoxide dismutase and catalase levels, the degree of which depends on the degree of obesity. One form of compensation for breach of antioxidant defense in chronic obstructive pulmonary disease in conjunction with obesity is increasing ceruloplasmin and activities of glutathione peroxidase and glutathione-S-transferase levels, most pronounced in the third-degree obesity.