https://dspace.bsmu.edu.ua/handle/123456789/1073 2026-04-14T12:41:12Z https://dspace.bsmu.edu.ua/handle/123456789/26496 Title: Association of Lipids’ Metabolism with Vitamin D Receptor (rs10735810, rs222857) and Angiotensinogen (rs699) Genes Polymorphism in Essential Hypertensive Patients Authors: Repchuk, Yuliya; Sydorchuk, Larysa; Fedoniuk, Larysa; Nebesna, Zoia; Vasiuk, Valentyna; Sydorchuk, Andrii; Iftoda, Oksana Abstract: AIM: The purpose of this study was to analyze lipid metabolism changes in patients with EAH depending on the Vitamin D receptor (VDR rs2228570 (aka rs10735810)) and angiotensinogen (AGT rs699) genes polymorphism. CONCLUSIONS: The EAH risk increases with a reduced HDL-C level in the TC genotype carriers of the AGT gene and irrespective of VDR gene polymorphic variants. 2021-01-01T00:00:00Z https://dspace.bsmu.edu.ua/handle/123456789/26495 Title: Novel Genetics and Humoral Prognostic Markers of Left Ventricle Hypertrophy in Hypertensive Patients Authors: Voroniuk, Kseniia; Sydorchuk, Larysa; Repchuk, Yuliya; Sydorchuk, Andrii; Sydorchuk, Ruslan; Iftoda, Oksana Abstract: Aim: The aim is to evaluate the echocardiographic (Echo-CG) changes in patients with EAH depending on genes AGT (rs4762), GNB3 (rs5443), and some humoral markers. Conclusion: The polymorphic variants of the AGT (521 C>T) and GNB3 (825 C>T) genes are associated with myocardial structure changes in EAH patients. Hypovitaminosis D in hypertensive individuals is accompanied by LVM and LVMI increase but reliably only in women. 2024-01-01T00:00:00Z https://dspace.bsmu.edu.ua/handle/123456789/26494 Title: Angiotensinogen (AGT RS4762) and guanine nucleotide-binding protein BETA-3 (GNB3 RS5443) genes predict left ventricular hypertrophy in hypertensive patients Authors: Voroniuk, Kseniia; Sydorchuk, Larysa; Dzhuryak, Valentina; Sydorchuk, Andrii; Hinhuliak, Oleksandr; Sydorchuk, Ruslan; Iftoda, Oksana; Kushnir, Oksana Abstract: Abstract. This study aims to evaluate polymorphic variants of AGT (rs4762) and GNB3 (rs5443) genes as predictors of myocardium left ventricular hypertrophy (LVH) in patients with essential arterial hypertension (EAH). The case-control study involved 100 patients with EAH stage II, high-very high cardiovascular risk. There were 21% men, and 79% women; the average age was 59.86±6.22 years old. The control group consisted of 60 practically healthy subjects. AGT (rs4762) and GNB3 (rs5443) genotyping was performed by Real-Time PCR. As a result, centric LVH (ELVH) in EAH patients is more common in T-allele carriers of AGT gene (rs4762), CC-genotype subjects of GNB3 gene (rs5443) by 26.29% and 22.22%, respectively. Concentric LVH (CLVH) dominates in homozygous C-allele patients of AGT gene (rs4762), and T-allele of GNB3 gene (rs5443) by 29.13%, 22.22%, correspondingly. ELVH risk increases in hypertensive T-allele carriers of AGT gene (rs4762) 4.5 times and in CC-genotype of GNB3 gene (rs5443) almost 5 times. CLVH risk increases in CC-genotype patients of AGT gene (rs4762) almost 5 times, in T-allele of GNB3 gene more than 4 times. Blood pressure (BP) ≥160/≥100mmHg increases ELVH risk 3 times. In conclusion, LV hypertrophic models associate with AGT (rs4762) and GNB3 (rs5443) genes polymorphic variants in hypertensive patients, as well as ELVH with BP elevation. 2023-01-01T00:00:00Z https://dspace.bsmu.edu.ua/handle/123456789/26493 Title: Роль оздоровчого харчування в реабілітаційному лікуванні пацієнтів із постковідним синдромом (перший досвід) Authors: Волошин, Олександр Іванович; Власик, Леонід Іванович; Волошина, Лариса Олександрівна; Айнуссі, Н.; Сухолотюк, А.Л.; Voloshyn, O.; Vlasyk, L.; Voloshyna, L.; Ainussi, N.; Sukholotyuk, A. Abstract: Мета. Підвищити ефективність реабілітації хворих із помірними проявами ПКС шляхом додаткового застосування оздоровчого харчування із використанням фруктів, овочів та спецій з особливими профілактичними властивостями. Висновок. Пацієнтам, які перенесли гострий етап ковід-інфекції з подальшим розвитком ПКС, в якості варіанту комплексної реабілітації доцільно застосовувати дієту з використанням інгредієнтів з високими оздоровчими властивостями (спеції, ягоди, фрукти, овочі, тощо). The objective is to increase the effectiveness of rehabilitation of patients with moderate manifestations of PCS through the additional use of health foods using fruits, vegetables and spices with special prophylactic properties. Conclusion. Patients who have suffered an acute stage of covid infection with the subsequent development of PCS as a variant of comprehensive rehabilitation, it is advisable to use a diet using ingredients with high health properties (spices, berries, fruits, vegetables, etc.). 2021-01-01T00:00:00Z