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POLYFUNCTIONAL PYRAZOLES. 9*. SYNTHESIS OF 1-ALKYL(ARYL)-3-[4-(HYDROXYMETHYL)-1Н-PYRAZOL-3-YL]UREAS

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dc.contributor.author Bratenko, M.K.
dc.contributor.author Barus, M.M.
dc.contributor.author Rotar, D.V.
dc.contributor.author Vovk, M.V.
dc.date.accessioned 2015-11-02T12:14:01Z
dc.date.available 2015-11-02T12:14:01Z
dc.date.issued 2014
dc.identifier.uri http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/9748
dc.description.abstract We have developed an effective method for the preparation of 1-alkyl(aryl)-3-[4-(hydroxymethyl)-1Н-pyrazol-3-yl]ureas based on the interaction of 4-hydroxymethylpyrazole-3-carbonyl azides with primary aliphatic and aromatic amines under the conditions of Curtius reaction. In the absence of amines in the reaction mixture, in situ generated 4-hydroxymethyl-3-isocyanatopyrazoles underwent intramolecular cyclization to pyrazolo[3,4-d][1,3]oxazin-6(4Н)-ones. The latter showed a tendency to form 1-alkyl(aryl)-3-[4-(hydroxymethyl)-1Н-pyrazol-3-yl]ureas in the presence of amines. ru_RU
dc.language.iso en ru_RU
dc.publisher Chemistry of Heterocyclic Compounds ru_RU
dc.relation.ispartofseries Vol. 50, No. 9;P.1252-1258
dc.subject 4-hydroxymethylpyrazole-3-carbonyl azides ru_RU
dc.subject (pyrazol-3-yl)ureas, pyrazolo[3,4-d][1,3]ox-azines ru_RU
dc.subject intramolecular cyclization ru_RU
dc.title POLYFUNCTIONAL PYRAZOLES. 9*. SYNTHESIS OF 1-ALKYL(ARYL)-3-[4-(HYDROXYMETHYL)-1Н-PYRAZOL-3-YL]UREAS ru_RU
dc.type Article ru_RU


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