INFLUENCE OF ALLELIC VARIANTS OF POLYMORPHIC GENES OF INTERLEUKINS, NITRIC OXIDE INDUCED SYNTHASE AND THEIR RECEPTORS IN THE COURSE OF HELICOBACTERASSOCIATED PEPTIC ULCER DISEASE IN CHILDREN

Abstract

This paper presents the results of the analysis of the distribution of allelic polymorphism of interleukin-1beta gene, -8, receptor antagonist and interleukin-1-induced NO-synthase in children of Chernivtsi region suffering from stomach ulcer and duodenal ulcer and healthy ones. It has been established that susceptibility to peptic ulcer disease is associated with the presence of the following genotypes: IL-1β-511C/C, R4/R4 IL-1Ra, IL-8-251A/T and C/C G954C in the promoter area of the gene induced NOsynthase.