Pharmacogenetic aspects of basic anti- inflammatory   therapy of bronchial asthma in school-aged children under   the deletion polymorphism of genes Gstt1 and Gstm1

dc.contributor.author	Koloskova, O.K.	en
dc.contributor.author	Bilous, T.M.	en
dc.contributor.author	Mikaliuk, L.V.	en
dc.contributor.author	Ortemenka, E.P.	en
dc.date.accessioned	2015-02-26T07:41:28Z
dc.date.available	2015-02-26T07:41:28Z
dc.date.issued	2014
dc.identifier.uri	http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/8256
dc.description.abstract	Based on a comprehensive survey of 150 school-age children who suffer from bronchial asthma, there has been found that homozygosity for both alleles of the gene of glutathione transferase (GSTT1+ M1+) was associated with more frequent use both inhaled corticosteroids at 3 Step 3 of basic therapy and leukotriene modifiers as well as better asthma control level according to the ACT-test. Under the presence of such genotypes as GSTT1+ M1-, GSTT1-M1+ or GSTT1-M1-, the basic treatment was more likely within 2-nd and 4-th Steps by GINA recommendations, but the level of asthma control was worse in these children.	ru_RU
dc.language.iso	en	ru_RU
dc.relation.ispartofseries	THE PHARMA INNOVATION - JOURNAL ;Vol. 2 No. 12.
dc.subject	bronchial asthma	ru_RU
dc.subject	children	ru_RU
dc.subject	glutathione-S-transferase	ru_RU
dc.title	Pharmacogenetic aspects of basic anti- inflammatory therapy of bronchial asthma in school-aged children under the deletion polymorphism of genes Gstt1 and Gstm1	ru_RU
dc.type	Article	ru_RU