Endothelium function biomarkers and carotid intima-media thickness changes in relation to NOS3 (rs2070744) and GNB3 (rs5443) genes polymorphism in the essential arterial hypertension

Sydorchuk, Andrii R.; Sydorchuk, Larysa P.; Gutnitska, Adelina F.; Dzhuryak, Valentina S.; Kryvetska, Inna I.; Sydorchuk, Ruslan I.; Ursuliak, Yulia V.; Iftoda, Oksana M.

Endothelium function biomarkers and carotid intima-media thickness changes in relation to NOS3 (rs2070744) and GNB3 (rs5443) genes polymorphism in the essential arterial hypertension

Sydorchuk, Andrii R.; Sydorchuk, Larysa P.; Gutnitska, Adelina F.; Dzhuryak, Valentina S.; Kryvetska, Inna I.; Sydorchuk, Ruslan I.; Ursuliak, Yulia V.; Iftoda, Oksana M.

URI: http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/26487

Дата: 2022

Короткий опис(реферат):

Objective. The aim of the present study was to clarify the endothelial function biomarkers and carotid “intima media” thickness (IMT) changes in relation to GNB3 (rs5443) and NOS3 (rs2070744) genes polymorphism in the essential arterial hypertension (EAH). Conclusion. NOS3 (rs2070744), but not GNB3 (rs5443), gene associated with the essential arterial hypertension severity relying upon the endothelial function impairment and NOS3 genes reduced transcription activity.

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