Studying qualitative characteristics of bone tissue of the human maxilla on the quantitative content of trace elements (K, Fe, Co, Sr, Zn) in the dynamics of prenatal ontogenesis

Abstract

Purposes. The updated and substantiated understanding of the patterns of the upper jaw growth in prenatal ontogenesis contributes both to the diagnosis of congenital malformations and the prevention of prenatal injury to the maxillofacial area. In this regard, determining the density of bone tissue, that is, its mineralization, whose impairment forms the basis for the development of various defects, is as important as studying inter-tissue relations in the process of histo- and organogenesis, including epithelio-mesenchymal ones. This research was conducted to study the quantitative con-tent of trace elements (K, Fe, Co, Sr, Zn) in the dynamics of prenatal ontogenesis as a fundamental material of bone tissue. The research was carried out as part of the implementation of a fragment of the planned comprehensive research work “Features of morphogenesis and structural and functional peculiarities of tissues and organs in human ontogenesis”, No. of state registration 0116U002938. Conclusion. Our study have found that the age dynamics of all values of the trace elements content in the prenatal ontogenesis of the upper jaw of human fetuses significantly correlates with both the decrease and growth – in the first (11-16 weeks of IUD), the second (17-24 IUD), the third (25-29 weeks of IUD) and the fourth (30-40 weeks of IUD) experimental groups, which is directly proportional to the redistribution of trace elements for the construction of organs and systems in these age periods. The regularity of the dependence and ratio of the content of cobalt (Co) and iron (Fe) in the first, second and third experimental groups was studied. There was a slight correlation between dependence and direct correlation (Fig. 2) on the reduction of zinc (Zn) and iron (Fe) in all groups. Studying the patterns of dynamics of the density of bone tissue of the upper jaw in human fetuses, depending on the mineral composition and the presence of the revealed synchronism of these processes, suggests that the change in density is indicative of a change in the content of certain mineral elements. In our opinion, this provision may be the basis for the development of new techniques for early diagnosis of congenital anomalies of the maxillofacial area at the preclinical stages of its development and the methods of their prevention, through the correction of the mineral composition.