The state of prooxidant system in rats’ kidneys under alcoholic intoxication and its combination with light exposure

Abstract

Although the negative effects of excessive alcohol consumption are generally known in the human population, drinking alcoholic beverages is prevalent in society. According to WHO, alcohol abuse contributes to three million deaths per year globally and millions of people’s disabilities and organ damage. In modern life, the use of ethanol is often combined with the influence of other harmful factors, such as the violation of the light regime. A modern person is exposed to light almost all the time. Night shifts, flights, jet lag and active nightlife contribute to the disturbance of circadian rhythms. Normally, the biological rhythms are regulated by melatonin, which is known to be secreted in the dark. Even a slight lighting inhibits its synthesis. It has been shown that melatonin has a wide range of biological effects but its main feature is a powerful antioxidant action.