The influence of melatonin upon the immunohistochemical status of melatonin type 1a receptors in the neurons of the supraoptic nucleus of the hypothalamus under light stress

Abstract

Biological rhythms are a fundamental property of the organic world, which ensures the organism's ability to adapt and survive in cyclically changing environmental conditions. One of the important links of the neuroendocrine system of the hypothalamus is the supervisory supraoptic nuclei (SON). They are involved in ensuring the neuroendocrine response to various types of stress - immobilization, pain, hypoxia, light, and other stress. Numerous clinical and experimental data indicate the key role of melatonin (MT) in the regulation of the main circadian rhythm of the body - the sleep-wake cycle. Receptors to MT have been found in various nuclei of the hypothalamus, retina, neurogenic tissues, etc.