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Caspase-8 and caspase-3 activity in lymphocyte lysate of patients with chronic obstructive pulmonary disease and intestinal dysbiosis

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dc.contributor.author Koval, Halyna
dc.contributor.author Olenovych, Olha
dc.date.accessioned 2012-06-11T12:59:42Z
dc.date.available 2012-06-11T12:59:42Z
dc.date.issued 2011
dc.identifier.uri http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/1736
dc.description.abstract With the aim to define the role of lymphocyte apoptosis in the mechanisms of T-cell deficiency in patients with chronic obstructive pulmonary disease (COPD) accompanied by the disturbances of intestinal microbiocynosis, the investigation of caspases activity in lysate of lymphocytes was conducted. III degree of dysbiosis was found to be followed by the reduction of CD3+- and CD8+-cells number, and in patients with IV degree of intestinal microbiocynosis the level of lymphocytes of CD3+, CD4+, CD8+ phenotypes decreased in the peripheral blood, followed by the inhibition of phytohaemagglutinin (PHA) induced lymphocyte blast transformation. The activity of caspase-8, caspase-3 and caspase-1 in lymphocyte lysate of patients with COPD was of high rates in dysbiosis of III and IV degree. ru_RU
dc.publisher Pharmacologyonline ru_RU
dc.subject chronic obstructive pulmonary disease ru_RU
dc.subject dysbiosis ru_RU
dc.subject lymphocytes ru_RU
dc.subject apoptosis ru_RU
dc.subject immune deficiency ru_RU
dc.subject хронічне обструктивне захворювання легень ru_RU
dc.subject дисбіоз ru_RU
dc.subject лімфоцити ru_RU
dc.subject апоптоз ru_RU
dc.subject імунодефіцит ru_RU
dc.subject хроническая обструктивная болезнь легких ru_RU
dc.subject дисбиоз ru_RU
dc.subject лимфоциты ru_RU
dc.subject апоптоз ru_RU
dc.subject иммунодефицит ru_RU
dc.title Caspase-8 and caspase-3 activity in lymphocyte lysate of patients with chronic obstructive pulmonary disease and intestinal dysbiosis ru_RU
dc.type Article ru_RU


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