Abstract:
Introduction. The study of anti-ovarian autoantibodies
in patients with ovarian insufficiency against the
background of normal levels of gonadotropins, prolactin
and androgens shows that the incidence of autoimmune
oophoritis among such women varies from
19.2% to 31.5%.
The objective of the study was to study the anti-
ovarian antibodies level in infertile women at the
preparatory stage for in vitro fertilization.
Materials and methods. We examined 30 women,
who were divided into the following groups: control
group – 10 reproductively healthy women, who had
a birth in the history (from 1 to 3); study group – 20
women with infertility of tube origin, who were included
in the in vitro fertilization program. The study
was performed between 2015-2017 in the Bukovinian
State Medical University and Centre of Reproductive
Medicine, Ukraine. The women signed the informed
consent.
Results. The anti-ovarian antibodies level in infertile
women was found out to be 1.7 times less than in
the control group. Reduction of the level of anti-ovarian
antibodies in patients from the study group was
marked by the obstetric and gynecological history.
Conclusions. Anti-ovarian antibodies are present in
both reproductively healthy women and in patients
with infertility. The level of anti-ovarian antibodies
can be both increased and reduced, depending on the
pathological process that caused infertility. In both
cases, this fact can testify the infertility. After plasmapheresis,
the increased level of anti-ovarian antibodies
sharply decreases.
