FUNCTIONAL RENAL STATE OF MATURE RATS WITH A QUICK TYPE OF ACETYLATION UNDER CONDITIONS OF CADMIUM CHLORIDE AND SODIUM NITRATE COMBINED EFFECT

Abstract

The experiments conducted on laboratory non-linear albino mature male rats with a quick type of acetylation examined renal function under conditions of cadmium-nitrate intoxication. A combined introduction of cadmium chloride (0,1 mg/kg, intraperitoneally) and sodium nitrate (500 mg/kg, intragastrically) during 14 days was found to result in increased glomerular filtration rate, activation of water excretory and renal excretory functions, increased proximal reabsorption of sodium ions. Retention of tubular mechanisms of sodium metabolism regulation and glomerular-tubular balance are indicative of quick acetylizer adaptive possibilities of the kidneys of mature rats ensuring maintenance of water-electrolytic balance under conditions of subacute cadmium-nitrate effect. Examination of a combined action of cadmium chloride and sodium nitrate of slow acetylizers on mature rats is a promising one with a comparative analysis of the renal function with the purpose to assess prognostic value of phenotype acetylation for the development of nephropathy.