Abstract:
Studies concerning the local and systemic use of ozonotherapy confirm its effectiveness compared to other physical methods. Therapeutic ozone concentrations (in a physiological solution from 1 mg/l to 6 mg/l, on average 3-4 mg/l with a single dose of 1.2-1.6 mg) activate the immunomodulatory function of the body. When administering ozone on the membranes of phagocytic cells (leukocytes, monocytes, macrophages) hydrophilic compounds are adsorbed. Ozonides stimulate cytokines, which, in their turn, promote activation of cellular and humoral immunity, and increases the rate of body’s nonspecific protection system.
However, the effect of ozone on pyoinflammatory state of the soft tissues, depending on the administered dose and severity of the process [1-3,8,10], have not been adequately evaluated in patients with diabetes mellitus.
