THE EFFECT OF NADP ON SOME VALUES OF THE RENAL ACID- REGULATING FUNCTION AT EXPERIMENTAL DIABETES MELLITUS

Abstract

Diabetes is a significant social problem, since it leads both to disability and high mortality rate. The experiment involved 32 sexually mature nonlinear males of white rats. Experimental groups of animals were administered a single streptozotocin dose of 70 mg/kg intraperitoneally and NADP – 30 mg/kg. The animals in the experimental groups were slaughtered and studied on the 11 th , 21 st and 31 st days after streptozotocin administration. The studies have shown that NADP affects the metabolism, reduces the production of acids and, as a result, reduces the excretion of acids by the kidneys in experimental animals.