Аннотации:
The article presents data about the stages of experimental diabetes mellitus under
conditions of the streptozotocin administration. It is noted that in the early development of
experimental diabetes, changes in the kidneys proceeds in three stages: physiological
adaptation; increasing morphological and functional changes and maladaptation;
pathophysiological stage. The data related to changes in glomerular filtration rate, acid
excretion, individual morphological alterations, etc. are given. The indicated changes in the
opinion of the authors indicate an adaptive reaction of the system of regulation of water-salt
metabolism and its main effector organ - the kidneys - to hyperosmia, caused by
hyperglycemia with the subsequent formation of diabetic nephropathy.
