Abstract:
Performed integral estimation of the diagnostic value of the obtained clinicalparaclinical parameters is indicative of a sufficient amount of reliable markers in verification of
severe bronchial asthma (BA) in children. Children with severe bronchial asthma are
characterized by the following phenotype peculiarities: early debut of the disease (chance ratio
(CR) = 1,5 (95% confidence interval (CI) 0,9-2,7), comorbid allergic diseases available
(allergic rhinitis and atopic dermatitis) (CR 2,7 (95% CI 1,5-4,8) and drug-induced or
comorbid drug-induced and food or domestic allergy (CR=4,8 (95% CІ 0,1-36,5)), infectious
index more than 2 (CR=3,3 (95% CІ 1,6-6,7), seasonal exacerbation of BA mainly from
November to March (СR=2,7 (95% CІ 1,5-4,9), associated with a trigger role of acute
respiratory viral infection (ARVI) (СR=5,5 (95% CІ 2,4-12,6) and meteorological factors
(СR=3,8 (95% CІ 0,4-36,4)
