Abstract:
The experimental studies conducted allow determining the critical parameters and their effect on the
manufacturing process of oil extracts of the composition of the herbal raw material with the hepatoprotective
action. The influence of the particle size of the raw material, concentration and the amount of
ethanol on moistening of the phytocomposition and the temperature of extraction has been studied. As
a result of the study the optimal parameters of extraction with the oil extractants providing efficiency of
the active substances release from the herbal raw material have been determined. They are grinding
of the herbal raw material by a screw shredder, an extractant for moistening is 70% ethanol in the
amount of 0.6±0.1 ml per 1.0 of the raw material; the swelling time – 2.0±0.5 h; the temperature of
extraction – 55±5ºС. According to the certain critical points of the manufacturing process the flowchart
of manufacturing the combined oil herbal medicinal product under the conditional name “Оleosil” has
been developed.
