Abstract:
The results of screening of 2-(benzoyilamino)(1-R-2-oxoindolin-3-ylidene)acetic acid derivatives on
the antihypoxic activity are presented in the article. It has been determined that under the conditions
of acute hypоbaric hypoxia compounds 4, 14 and 15 have shown the increase of the integral index
of the antihypoxic activity of substances – the overall lifetime of animals at the “high-altitude plateau”.
However, the mortality rate of animals reached 20% for compound 4, and it signifi cantly exceeded
the control data. At the same time, compound 14 by its antihypoxic activity signifi cantly increased the
overall lifetime of animals by 150% compared to the control data, but its effect was signifi cantly weaker
than the effect of the reference drug mexidol, which increased the lifetime of animals by 197% (p<0.05). For
compound 15 the overall lifetime of animals increased by 186% compared to the control data (p<0.05)
and did not differ signifi cantly from that of the reference drug. The data obtained indicate that most
of the substances studied – derivatives of 2-(benzoyilamino)(1-R-2-oxoindolin-3-ylidene)acetic acid –
demonstrate certain antihypoxic properties, as well as derivatives of 2-(2-oxoindolin-3-ylidene)acetic
acid previously researched. Moreover, only compound 15 corresponds to the antihypoxic effi cacy of
the reference drug, and by the index of recovery of the animals’ physical activity after their staying at
the “high-altitude plateau” (the posture recovery time) it exceeds the effect of the antihypoxant drug
mexidol.
