Abstract:
The aim of the work was to increase the effectiveness of treatment severe asthma phenotype in school-age children, taking into account the diagnostic value of atopic reactivity indicators. The study involved 30 pupils with severe asthma and 30 children with moderate-heavy version of it. Amid severe asthma increases risk of higher concentrations of IL-4 and IL-5 in the serum, and almost every second child observed increased concentrations of Ig E (more than 545,3 IU/mL, odds ratio was 1,9 (95% CI 1,1-3,4). In the group of patients with severe asthma were significantly more frequent cases of the skin hypersensitivity to household allergens with respect to the members of the second group. It was indices clinical and epidemiological risk and diagnostic value of the some markers of atopic reactivity for verification phenotype of severe asthma. It was established that the development of severe asthma in children marked tendency to reduce the metabolic activity of eosinophilic granulocytes in blood (in terms of intracellular content of cationic proteins and peroxidase) and phagocytic ability of these effector cells of allergic inflammation. For the phenotype of severe asthma in 3,1 times increased the risk of high concentration of IL-4 and IL-5 in serum, but this paraclinical test rather suitable for verification of this phenotype (SP – 84,6% (95% Sp 75,9-91,1)) than for its detection (Se – 36,4% (95% CI 26,9-46,6)).
