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dc.contributor.author Slyvka, Nataliia Oleksyivna
dc.contributor.author Virstiuk, Nataliia Grygorivna
dc.contributor.author Samsonyuk, V.O.
dc.contributor.author Popovych, O.V.
dc.contributor.author Kostiv, U.I.
dc.date.accessioned 2016-09-28T10:00:49Z
dc.date.available 2016-09-28T10:00:49Z
dc.date.issued 2016-03
dc.identifier.uri http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/11486
dc.description.abstract The research was aimed to investigate the use of cystatin C (CysC) for early detection of hepatorenal syndrome (HRS) in cirrhotics. CysC, a low-molecular-weight cysteine proteinase inhibitor, is a potentially more accurate marker of glomerular filtration. We conducted a prospective multicenter study in patients with alcoholic liver cirrhosis, comparing changes in CysC and serum creatinine (Scr) immediately following onset of HRS as predictors of a composite endpoint of dialysis or mortality. The results of our study confirmed, that CysC has demonstrated less variability between samples than Scr. Patients were stratified into four groups reflecting changes in Scr and cystatin: both unchanged or decreased 38 (36%) (Scr−/CysC−); only cystatin increased 25 (24%) (Scr−/CysC+); only Scr increased 15 (14%) (Scr+/CysC−); and both increased 28 (26%) (Scr+/CysC+). With Scr−/CysC− as the reference, in both instances where cystatin rose, Scr−/CysC+ and Scr+/CysC+, the primary outcome was significantly more frequent in multivariate analysis, and, respectively. However, when only Scr rose, outcomes were similar to the reference group. Summarizing all above, we can conclude, that changes in CysC levels early in HRS are more closely associated with eventual dialysis or mortality, than Scr and may allow more rapid identification of patients at risk for adverse outcomes. ru_RU
dc.language.iso en_US ru_RU
dc.publisher I Международная научно-практическая конференция "Инновации в науке: теория и практика". - Вена, Австрия - март 10, 2016 г. ru_RU
dc.subject hepatorenal syndrome ru_RU
dc.subject cystatin C ru_RU
dc.subject alcoholic liver cirrhosis ru_RU
dc.title CYSTATIN C AS AN EARLY MARKER OF HEPATORENAL SYNDROME ru_RU
dc.type Article ru_RU


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Показати скорочений опис матеріалу