Интеллектуальные Фонды БГМУ
Effect of DIO1 and GPX1 gene polymorphism on the functional condition of the endothelium in patients with chronic diffuse liver disease
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| dc.contributor.author | Chympoy, K.A. | |
| dc.contributor.author | Pashkovska, N.V. | |
| dc.contributor.author | Olinyk, O.Ju. | |
| dc.contributor.author | Teleki, Ja.M. | |
| dc.date.accessioned | 2016-06-08T09:54:09Z | |
| dc.date.available | 2016-06-08T09:54:09Z | |
| dc.date.issued | 2015 | |
| dc.identifier.uri | http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/10994 | |
| dc.description.abstract | In patients with chronic diffuse liver diseases there is a relation between the expression of Pro197Leu polymorphism of GPX1 gene and indices of cellular adhesion, which is revealed by a reliably higher content of soluble intercellular adhesion molecule-1 type in the blood serum in homozygotic carriers of Leu-allele. Changes of the endothelial functional state in patients with chronic diffuse liver diseases are associated with Pro197Leu polymorphism of GPX1 gene, which is proved by a reliably higher index of desquamated endotheliocytes amount and lower level of NO metabolites in the carriers of LeuLeu-genotype. Examination of the indices of cellular adhesion and functional endothelial state in patients with chronic diffuse liver diseases did not reveal their dependence on the distribution of A/C polymorphism of DIO1 gene. | ru_RU |
| dc.language.iso | en | ru_RU |
| dc.publisher | International scientific-practical congress of pedagogues, psychologists and medics (5 th June, 2015, Geneva). – P. 231-238. | ru_RU |
| dc.subject | chronic diffuse liver diseases | ru_RU |
| dc.subject | хронические диффузные заболевания печени | ru_RU |
| dc.subject | хронічні дифузні захворювання печінки | ru_RU |
| dc.subject | gene polymorphism | ru_RU |
| dc.subject | endothelium | ru_RU |
| dc.subject | полиморфизм гена | ru_RU |
| dc.subject | эндотелий | ru_RU |
| dc.subject | поліморфізм гену | ru_RU |
| dc.subject | ендотелій | ru_RU |
| dc.title | Effect of DIO1 and GPX1 gene polymorphism on the functional condition of the endothelium in patients with chronic diffuse liver disease | ru_RU |
| dc.type | Article | ru_RU |
