Интеллектуальные Фонды БГМУ

Effect of DIO1 and GPX1 gene polymorphism on the functional condition of the endothelium in patients with chronic diffuse liver disease

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dc.contributor.author Chympoy, K.A.
dc.contributor.author Pashkovska, N.V.
dc.contributor.author Olinyk, O.Ju.
dc.contributor.author Teleki, Ja.M.
dc.date.accessioned 2016-06-08T09:54:09Z
dc.date.available 2016-06-08T09:54:09Z
dc.date.issued 2015
dc.identifier.uri http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/10994
dc.description.abstract In patients with chronic diffuse liver diseases there is a relation between the expression of Pro197Leu polymorphism of GPX1 gene and indices of cellular adhesion, which is revealed by a reliably higher content of soluble intercellular adhesion molecule-1 type in the blood serum in homozygotic carriers of Leu-allele. Changes of the endothelial functional state in patients with chronic diffuse liver diseases are associated with Pro197Leu polymorphism of GPX1 gene, which is proved by a reliably higher index of desquamated endotheliocytes amount and lower level of NO metabolites in the carriers of LeuLeu-genotype. Examination of the indices of cellular adhesion and functional endothelial state in patients with chronic diffuse liver diseases did not reveal their dependence on the distribution of A/C polymorphism of DIO1 gene. ru_RU
dc.language.iso en ru_RU
dc.publisher International scientific-practical congress of pedagogues, psychologists and medics (5 th June, 2015, Geneva). – P. 231-238. ru_RU
dc.subject chronic diffuse liver diseases ru_RU
dc.subject хронические диффузные заболевания печени ru_RU
dc.subject хронічні дифузні захворювання печінки ru_RU
dc.subject gene polymorphism ru_RU
dc.subject endothelium ru_RU
dc.subject полиморфизм гена ru_RU
dc.subject эндотелий ru_RU
dc.subject поліморфізм гену ru_RU
dc.subject ендотелій ru_RU
dc.title Effect of DIO1 and GPX1 gene polymorphism on the functional condition of the endothelium in patients with chronic diffuse liver disease ru_RU
dc.type Article ru_RU


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