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ROLE OF MATRIX METALLOPROTEINASES IN THE DEVELOPMENT OF ENDOMETRIOSIS IN WOMEN WITH INFERTILITY

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dc.contributor.author Koval, H.D.
dc.contributor.author Olenovych, O.A.
dc.date.accessioned 2016-05-23T09:55:58Z
dc.date.available 2016-05-23T09:55:58Z
dc.date.issued 2015
dc.identifier.uri http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/10794
dc.description.abstract The expression of matrix metalloproteinases 2, 9 and 11 (MMP-2, MMP-9, MMP-11) was investigated in 20 samples of the endometriotic tissue from women with endometriosis-associated infertility. The obtained results are indicative of the enhanced MMP-2 activity against the ground of endometriotic lesion and the peritoneum, as well as in capillaries and in the area of endometrial infiltration in underlying tissue. The elevation of MMP-9 activity was observed in the stroma of the ectopic endometrium bordering with underlying stroma. The intensified MMP-11 expression was found to prevail in outer membranes of endometrial cells. Thus, the obtained findings are indicative of the increased MMP-2, MMP-9 and MMP-11 activity in the sites of endometriotic lesion, that, considering their ability to demonstrate lytic and remodeling action upon underlying connective tissue, may promote endometrial cells infiltration into the underlying tissue (peritoneum), improve capillary permeability and involvement of macrophage and lymphocyte cellular components with further formation of infiltrates. Therefore, the investigation results evidence the role of matrixmetalloproteinases in the progression of endometriosis. ru_RU
dc.language.iso en ru_RU
dc.publisher Pharmacologyonline. – 2015. – Vol.3. – Р.14-18. ru_RU
dc.subject endometriosis, infertility, matrix metalloproteinases ru_RU
dc.subject ендометріоз, безпліддя, матричні металопротеїнази ru_RU
dc.subject эндометриоз, бесплодие, матричные металлопротеиназы ru_RU
dc.title ROLE OF MATRIX METALLOPROTEINASES IN THE DEVELOPMENT OF ENDOMETRIOSIS IN WOMEN WITH INFERTILITY ru_RU
dc.title.alternative РОЛЬ МАТРИЧНИХ МЕТАЛОПРОТЕЇНАЗ В РОЗВИТКУ ЕНДОМЕТРІОЗУ У ЖІНОК З БЕЗПЛІДДЯМ ru_RU
dc.title.alternative РОЛЬ МАТРИЧНЫХ МЕТАЛЛОПРОТЕИНАЗ В РАЗВИТИИ ЭНДОМЕТРИОЗА У ЖЕНЩИН С БЕСПЛОДИЕМ ru_RU
dc.type Article ru_RU


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