POLYFUNCTIONAL PYRAZOLES. 9*. SYNTHESIS OF 1-ALKYL(ARYL)-3-[4-(HYDROXYMETHYL)-1Н-PYRAZOL-3-YL]UREAS

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DC Field	Value	Language
dc.contributor.author	Bratenko, M.K.
dc.contributor.author	Barus, M.M.
dc.contributor.author	Rotar, D.V.
dc.contributor.author	Vovk, M.V.
dc.date.accessioned	2015-11-02T12:14:01Z
dc.date.available	2015-11-02T12:14:01Z
dc.date.issued	2014
dc.identifier.uri	http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/9748
dc.description.abstract	We have developed an effective method for the preparation of 1-alkyl(aryl)-3-[4-(hydroxymethyl)-1Н-pyrazol-3-yl]ureas based on the interaction of 4-hydroxymethylpyrazole-3-carbonyl azides with primary aliphatic and aromatic amines under the conditions of Curtius reaction. In the absence of amines in the reaction mixture, in situ generated 4-hydroxymethyl-3-isocyanatopyrazoles underwent intramolecular cyclization to pyrazolo[3,4-d][1,3]oxazin-6(4Н)-ones. The latter showed a tendency to form 1-alkyl(aryl)-3-[4-(hydroxymethyl)-1Н-pyrazol-3-yl]ureas in the presence of amines.	ru_RU
dc.language.iso	en	ru_RU
dc.publisher	Chemistry of Heterocyclic Compounds	ru_RU
dc.relation.ispartofseries	Vol. 50, No. 9;P.1252-1258
dc.subject	4-hydroxymethylpyrazole-3-carbonyl azides	ru_RU
dc.subject	(pyrazol-3-yl)ureas, pyrazolo[3,4-d][1,3]ox-azines	ru_RU
dc.subject	intramolecular cyclization	ru_RU
dc.title	POLYFUNCTIONAL PYRAZOLES. 9*. SYNTHESIS OF 1-ALKYL(ARYL)-3-[4-(HYDROXYMETHYL)-1Н-PYRAZOL-3-YL]UREAS	ru_RU
dc.type	Article	ru_RU
Appears in Collections:	Статті. Кафедра медичної та фармацевтичної хімії

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