Changes of the nitrogen monoxide concentration in children with peptic ulcer disease

Abstract

The level of nitrogen monoxide is reliable elevated in the blood and saliva of Helicobacter pylori infected children with ulcer disease, it decreases by duration of disease more than 3 years, and by severe course of disease, does not depend on the age of children and localization of ulcer defect. There was the following distribution of iNOS (G954C) genotype in patients with UD: homozygotes for G-allele – 47,5%, heterozygotes – 38,3%, homozygotes for C-allele – 14,2%. The total prevalence of mutant C-allele of iNOS amounts 52,5%.