The Lipid Profile among Patients with Myocardial Infarction Depending on Allelic State of the Genes АСЕ (I/D) and eNOS (T894G)

Abstract

The changes in lipid profile among patients with acute myocardial infarction (AIM) depending on polymorphism of I/D gene АСЕ, T894G gene eNOS have been researched. The research revealed, that bearing ID-genotype of ACE gene and T-allele gene eNOS is associated with total cholesterol increase (TCI) by 7,88–17,8 %, and DD-genotype – with cholesterol degrease of high density lipoproteins by 38,7 % and 43,2 % accordingly. The complex treatment of AIM patients enhanced the numbers of patients with ‗target‘ TCI level and cholesterol of low density lipoproteins by 44,4 % and 52,4 % accordingly among ID-genotype bearers ACE and T-allele of eNOS gene by 51,1–60,9 %, bearers of II/TG, ID/TT, ID/TG, DD/GG and DD/TG haplotypes – by 29,5–48,6 %.